Article
Knockdown of nuclear Ca2+/calmodulin-dependent protein kinase phosphatase causes developmental abnormalities in zebrafish.
Archives of biochemistry and biophysics - 15 Jan 2007
Nimura Takaki, Sueyoshi Noriyuki, Ishida Atsuhiko, Yoshimura Yukihiro, Ito Makoto, Tokumitsu Hiroshi, Shigeri Yasushi, Nozaki Naohito, Kameshita Isamu
Abstract excerpt
Nuclear Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP-N) is an enzyme that dephosphorylates and concomitantly downregulates multifunctional Ca2+/calmodulin-dependent protein kinases (CaMKs) in vitro. However, the functional roles of this enzyme in vivo are not well understood. To investigate the biological significance of CaMKP-N during zebrafish embryogenesis, we cloned and characterized zebrafish...
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