Article
Specificity of human cathepsin G.
Biochimica et biophysica acta - 28 Jul 1998
Polanowska J, Krokoszynska I, Czapinska H, Watorek W, Dadlez M, Otlewski J
Abstract excerpt
A series of tetrapeptide p-nitroanilide substrates of the general formula: suc-Ala-Ala-Pro-Aaa-p-nitroanilide was used to map the S1 binding pocket of human cathepsin G. Based on the kcat/Km parameter, the following order of preference was found: Lys=Phe>Arg=Leu>Met>Nle=Nva>Ala>Asp. Thus, the enz...
Topics
- Amino Acid Sequence
- Aniline Compounds
- Aprotinin
- Cathepsin G
- Cathepsins
- Humans
- Models, Chemical
- Molecular Sequence Data
- Mutation
- Oligopeptides
- Plant Proteins
- Sequence Homology, Amino Acid
- Serine Endopeptidases
- Serine Proteinase Inhibitors
- Substrate Specificity