Article
Comparative study on specificities of rat cathepsin L and papain: amino acid differences at substrate-binding sites are involved in their specificities.
Journal of biochemistry - 1 Dec 1990
Koga H, Yamada H, Nishimura Y, Kato K, Imoto T
Abstract excerpt
Sixty-nine rat cathepsin L-susceptible peptide bonds were analyzed employing various peptide substrates. The proteolytic specificities of rat cathepsin L and papain were compared and the results are discussed in relation to differences in amino acid residues around their binding sites. The specif...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Cathepsin L
- Cathepsins
- Computer Graphics
- Cysteine Endopeptidases
- Endopeptidases
- Hydrolysis
- Male
- Molecular Sequence Data
- Mutation