Article

Rational design of human cathepsin L with efficient collagenolytic activity

2020-05-10

Abstract excerpt

Collagens are the main structural components of ECM and collagenolysis is vital for ECM remodelling, which is essential for normal organ homeostasis. Any dysregulation of this process can result in various pathological conditions. The degradation of the interstitial collagens is generally mediated by specific collagenases which are capable of cleaving at specific loci in the collagen triple helix. Lysosomal cystei...

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Literature Corpus work: ae2f0467-aad9-5155-9415-c4b91299d6ad
DOI: 10.1101/2020.05.10.087031

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