Article
Binding of amino acid side-chains to S1 cavities of serine proteinases.
Journal of molecular biology - 21 Feb 1997
Lu W, Apostol I, Qasim M A, Warne N, Wynn R, Zhang W L, Anderson S, Chiang Y W, Ogin E, Rothberg I, Ryan K, Laskowski M
Abstract excerpt
The P1 or primary specificity residue of standard mechanism canonical protein inhibitors of serine proteinases, inserts into the S1 primary specificity cavity of the cognate enzyme upon enzyme-inhibitor complex formation. Both natural evolution and protein engineering often change the P1 residue...
Topics
- Amino Acid Sequence
- Binding Sites
- Hydrogen-Ion Concentration
- Models, Chemical
- Molecular Sequence Data
- Mutation
- Ovomucin
- Peptide Fragments
- Proline
- Protein Binding
- Protein Conformation
- Recombinant Proteins
- Serine Endopeptidases
- Serine Proteinase Inhibitors
- Structure-Activity Relationship