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Article

Binding of amino acid side-chains to S1 cavities of serine proteinases.

Journal of molecular biology - 21 Feb 1997

Lu W, Apostol I, Qasim M A, Warne N, Wynn R, Zhang W L, Anderson S, Chiang Y W, Ogin E, Rothberg I, Ryan K, Laskowski M

Abstract excerpt

The P1 or primary specificity residue of standard mechanism canonical protein inhibitors of serine proteinases, inserts into the S1 primary specificity cavity of the cognate enzyme upon enzyme-inhibitor complex formation. Both natural evolution and protein engineering often change the P1 residue to greatly alter the specificity and the binding strength. To systematize such results we have obtained all 20 coded P1...

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Source

Identifiers

PMID: 9047374
DOI: 10.1006/jmbi.1996.0781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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