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Inhibitors of cathepsin G: a patent review (2005 to present)

30 Sept 2013

Abstract excerpt

INTRODUCTION: Cathepsin G (CatG) is a neutral proteinase originating from human neutrophils. It displays a unique dual specificity (trypsin- and chymotrypsin-like); thus, its enzymatic activity is difficult to control. CatG is involved in the pathophysiology of several serious human diseases, such as chronic obstructive pulmonary disease (COPD), Crohn's disease, rheumatoid arthritis, cystic fibrosis and other...

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PMID: 24079661
DOI: 10.1517/13543776.2013.835397

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