Allelic diversity is generated by intraexon sequence exchange at the DRB1 locus of primates.

doi:10.1073/pnas.88.9.3686

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Article

Allelic diversity is generated by intraexon sequence exchange at the DRB1 locus of primates.

Proceedings of the National Academy of Sciences of the United States of America - 1 May 1991

Gyllensten U B, Sundvall M, Erlich H A

Abstract excerpt

The loci encoding the class II cell surface antigens HLA-DR, -DQ, and -DP exhibit a remarkable degree of allelic polymorphism. Most of the class II allelic diversity is localized to the second exon, which encodes a beta-pleated sheet followed by an alpha-helical domain. Here, phylogenetic analysis of 39 human DRB1 alleles and 21 DRB1 alleles obtained by polymerase chain reaction (PCR) amplification from a set of...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Exons
Gorilla gorilla
HLA-DR Antigens
HLA-DRB1 Chains
Histocompatibility Antigens Class II
Humans
Macaca mulatta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Pan troglodytes

Phylogeny

Polymorphism, Genetic

Primates

Protein Conformation

Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2023919
DOI: 10.1073/pnas.88.9.3686
PMCID: PMC51517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2023919-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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