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Article

Dual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998

Valentin A, Lu W, Rosati M, Schneider R, Albert J, Karlsson A, Pavlakis G N

Abstract excerpt

We report that interleukin 4 (IL-4) inhibits the propagation of non-syncytia-inducing and increases the propagation of syncytia-inducing HIV-1 isolates by two mechanisms. It differentially regulates the two major HIV-1 coreceptors, CCR5 and CXCR4, in human peripheral blood mononuclear cells, increasing CXCR4 and decreasing CCR5 expression in primary CD4(+) T-lymphocytes. In addition, IL-4 stimulates the...

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Share to CD4-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9671774
DOI: 10.1073/pnas.95.15.8886
PMCID: PMC21172

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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