Article
Dual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998
Valentin A, Lu W, Rosati M, Schneider R, Albert J, Karlsson A, Pavlakis G N
Abstract excerpt
We report that interleukin 4 (IL-4) inhibits the propagation of non-syncytia-inducing and increases the propagation of syncytia-inducing HIV-1 isolates by two mechanisms. It differentially regulates the two major HIV-1 coreceptors, CCR5 and CXCR4, in human peripheral blood mononuclear cells, incr...
Topics
- CD4-Positive T-Lymphocytes
- Cloning, Molecular
- Disease Progression
- Giant Cells
- HIV-1
- Humans
- Interleukin-4
- Macrophages
- Phenotype
- RNA, Messenger
- Receptors, CCR5
- Transcription, Genetic