Article
Increased replication of non-syncytium-inducing HIV type 1 isolates in monocyte-derived macrophages is linked to advanced disease in infected children.
AIDS research and human retroviruses - 20 Mar 2002
Tuttle Daniel L, Anders Cynthia B, Aquino-De Jesus M Janette, Poole Paul P, Lamers Susanna L, Briggs Daniel R, Pomeroy Steven M, Alexander Louis, Peden Keith W C, Andiman Warren A, Sleasman John W, Goodenow Maureen M
Abstract excerpt
Non-syncytium-inducing (NSI) strains of HIV-1 prevail among most infected children, including pediatric patients who develop advanced disease, severe immune suppression, and die. A study was designed to address the hypothesis that genotypic and/or phenotypic markers can distinguish NSI viruses isolated during early infection from NSI viruses found in advanced disease. Primary HIV-1 isolates, which were obtained...
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