Article
Expression of chemokine receptors CXCR4 and CCR5 in HIV-1-infected and uninfected individuals.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1998
Ostrowski M A, Justement S J, Catanzaro A, Hallahan C A, Ehler L A, Mizell S B, Kumar P N, Mican J A, Chun T W, Fauci A S
Abstract excerpt
The chemokine receptors CXCR4 and CCR5 have been identified as major coreceptors for HIV-1 entry into CD4+ T cells. The majority of primary HIV-1 isolates in early disease use CCR5 as a coreceptor, whereas during disease progression with the emergence of syncytium-inducing viruses, CXCR4 is also...
Topics
- HIV Infections
- HIV Seronegativity
- HIV Seropositivity
- HIV-1
- Humans
- Leukocytes
- Lymphocyte Activation
- Male
- Middle Aged
- Phenotype
- Receptors, CCR5
- Receptors, CXCR4
- T-Lymphocytes