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Article

CCR5- and CXCR4-utilizing strains of human immunodeficiency virus type 1 exhibit differential tropism and pathogenesis in vivo.

Journal of virology - 1 Dec 1998

Berkowitz R D, Alexander S, Bare C, Linquist-Stepps V, Bogan M, Moreno M E, Gibson L, Wieder E D, Kosek J, Stoddart C A, McCune J M

Abstract excerpt

CCR5-utilizing (R5) and CXCR4-utilizing (X4) strains of human immunodeficiency virus type 1 (HIV-1) have been studied intensively in vitro, but the pathologic correlates of such differential tropism in vivo remain incompletely defined. In this study, X4 and R5 strains of HIV-1 were compared for tropism and pathogenesis in SCID-hu Thy/Liv mice, an in vivo model of human thymopoiesis. The X4 strain NL4-3 replicates...

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Identifiers

PMID: 9811751
DOI: 10.1128/JVI.72.12.10108-10117.1998
PMCID: PMC110545

Genes

CXCR4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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