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Article

The fickle finger of fate.

The Journal of clinical investigation - 1 Apr 2005

de la Fuente Luis, Helms Jill A

Abstract excerpt

In this issue of the JCI, Niedermaier and colleagues demonstrate that a chromosomal inversion in mice results in dysregulation of Sonic hedgehog (Shh), such that Shh is ectopically expressed in a skeletogenic domain typically occupied by Indian hedgehog (Ihh). This molecular reversal eliminates phalangeal joint spaces, and consequently, Short digits (Dsh) heterozygotes (Dsh/+) have brachydactyly (shortened...

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Share to Chromosome Inversion
Share to Foot
Share to Foot Deformities, Congenital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Hedgehog Proteins

Share to Morphogenesis

Share to Osteogenesis

Share to Trans-Activators

Source

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Identifiers

PMID: 15841172
DOI: 10.1172/JCI24840
PMCID: PMC1070437

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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