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Article

Mutational analysis reveals an essential role for the LXXLL motif in the transformation function of the human herpesvirus-8 oncoprotein, kaposin.

DNA and cell biology - 1 Jan 2005

Tomkowicz Brian, Singh Satya P, Lai Derhsing, Singh Anjali, Mahalingham Sundarasamy, Joseph Jeymohan, Srivastava Shiv, Srinivasan Alagarsamy

Abstract excerpt

Human herpesvirus-8 (HHV-8) is causally linked to Kaposi's sarcoma (KS). Sequence analysis of the genome and subsequent studies revealed several genes including kaposin, with transformation properties in cell culture. In this study, we have analyzed the requirement of Kaposin A for cellular transformation in an effort to understand its contribution towards KS pathogenesis. Comparative analysis of Kaposin with...

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Identifiers

PMID: 15684715
DOI: 10.1089/dna.2005.24.10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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