Article
NH2-terminal cleavage of xenopus fibroblast growth factor 3 is necessary for optimal biological activity and receptor binding.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Nov 2000
Antoine M, Daum M, Köhl R, Blecken V, Close M J, Peters G, Kiefer P
Abstract excerpt
Fibroblast growth factor 3 (FGF3) was originally identified as the mouse proto-oncogene Int-2, which is activated by proviral insertion in tumors induced by mouse mammary tumor virus. To facilitate the biological characterization of the ligand, we have analyzed its homologue in Xenopus laevis, XFGF3. Here we confirm that the X. laevis genome contains two distinct FGF3 alleles, neither of which is capable of...
Topics
- Alleles
- Amino Acid Motifs
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding, Competitive
- COS Cells
- Cell Transformation, Neoplastic
- Cloning, Molecular
- Conserved Sequence