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AXL receptor is required for Zika virus strain MR-766 infection in human glioblastoma cell lines

11 Nov 2021

Abstract excerpt

Recent reports have shown that Zika virus (ZIKV) has oncolytic potential against human glioblastoma (GBM); however, the mechanisms underlying its tropism and cell entry are not completely understood. The receptor tyrosine kinase AXL has been identified as an entry receptor for ZIKV in a cell-type-specific manner. Interestingly, AXL is frequently overexpressed in GBM patients. Using commercially available GBM cell...

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PMID: 34901388
DOI: 10.1016/j.omto.2021.11.001

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