Article
Allele-specific inactivation of the alpha4 integrin gene expression in fibrosarcoma cell lines and relevance for spontaneous metastasis.
Oncogene - 9 Jul 1998
Sato S, Tunashima K, Mafune Y, Ohtsuka H, Koide N, Endo Y, Saito Y, Asakura H, Kominami R
Abstract excerpt
Deregulated expression of genes is found in cancer cells, which may affect malignant properties, but it is unclear whether such modulation occurs allele-specifically. This study shows that the gene coding alpha4 integrin, a cell adhesion molecule, underwent allelic inactivation in a series of heterozygous murine fibrosarcoma cell lines (MST lines) with different metastatic potentials. P4 cells expressed the...
Topics
- Alleles
- Animals
- Antigens, CD
- DNA Methylation
- Female
- Fibrosarcoma
- Gene Expression Regulation
- Integrin alpha4
- Loss of Heterozygosity
- Male
- Mice
- Mice, Inbred C57BL
- Neoplasm Metastasis
- Tumor Cells, Cultured