Article
Allele-specific inactivation of the alpha4 integrin gene expression in fibrosarcoma cell lines and relevance for spontaneous metastasis.
Oncogene - 9 Jul 1998
Sato S, Tunashima K, Mafune Y, Ohtsuka H, Koide N, Endo Y, Saito Y, Asakura H, Kominami R
Abstract excerpt
Deregulated expression of genes is found in cancer cells, which may affect malignant properties, but it is unclear whether such modulation occurs allele-specifically. This study shows that the gene coding alpha4 integrin, a cell adhesion molecule, underwent allelic inactivation in a series of heterozygous murine fibrosarcoma cell lines (MST lines) with different metastatic potentials. P4 cells expressed the...
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