Gain-of-function mutations in FcgammaRI of NOD mice: implications for the evolution of the Ig superfamily.

doi:10.1093/emboj/17.14.3850

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Article

Gain-of-function mutations in FcgammaRI of NOD mice: implications for the evolution of the Ig superfamily.

The EMBO journal - 15 Jul 1998

Gavin A L, Tan P S, Hogarth P M

Abstract excerpt

It has been postulated that, during evolution of the Ig superfamily, modifications of the function of individual receptors might occur by acquisition of exons and their subsequent modification, though evidence of this is lacking. Here we have analysed the interaction of mouse IgG subclasses with...

Topics

Animals
Binding Sites
Bone Marrow
COS Cells
Evolution, Molecular
Exons
Immunoglobulin G
Introns
Macrophages
Mice
Mice, Inbred BALB C
Mice, Inbred NOD
Mutation
Receptors, IgG

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