Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination.

doi:10.1126/science.2139735

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Article

Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination.

Science (New York, N.Y.) - 11 May 1990

Qiu W Q, de Bruin D, Brownstein B H, Pearse R, Ravetch J V

Abstract excerpt

Receptors for immunoglobulin G immune complexes (Fc gamma RII and Fc gamma RIII) are expressed on most hematopoietic cells and show much structural and functional diversity. In order to determine the genetic basis for this diversity, a family of genes encoding the human and mouse receptors was isolated and characterized. Humans have five distinct genes for low-affinity Fc gamma Rs, in contrast to two in the...

Topics

Animals
Antigens, Differentiation
Base Sequence
Blotting, Southern
Exons
Genome, Human
Humans
Immunoglobulin G
Introns
Mice
Molecular Sequence Data
Multigene Family

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Receptors, Fc

Receptors, IgG

Recombination, Genetic

Restriction Mapping

Spleen

Source

Open in PubMed

Identifiers

PMID: 2139735
DOI: 10.1126/science.2139735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2139735-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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