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Article

Genetic dissection of a major haplotype associated with arthritis reveal FcγR2b and FcγR3 to act additively.

European journal of immunology - 1 Mar 2021

Vaartjes Daniëlle, Klaczkowska Dorota, Cragg Mark S, Nandakumar Kutty Selva, Bäckdahl Liselotte, Holmdahl Rikard

Abstract excerpt

A haplotype with tightly linked Fc gamma receptor (FcγR) genes is known as a major locus controlling immune responses and autoimmune diseases, including arthritis. Here, we split a congenic fragment derived from the NOD mouse (Cia9) to study its effect on immune response and arthritis in mice. We found that arthritis susceptibility was indeed controlled by the FcγR gene cluster and a recombination between the...

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Identifiers

PMID: 33244759
DOI: 10.1002/eji.202048605
PMCID: PMC7984332

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