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Article

B Cell Defects Observed in Nod2 Knockout Mice Are a Consequence of a Dock2 Mutation Frequently Found in Inbred Strains.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2018

Wong Serre-Yu, Coffre Maryaline, Ramanan Deepshika, Hines Marcus J, Gomez Luis E, Peters Lauren A, Schadt Eric E, Koralov Sergei B, Cadwell Ken

Abstract excerpt

Phenotypic differences among substrains of laboratory mice due to spontaneous mutations or pre-existing genetic variation confound the interpretation of targeted mutagenesis experiments and contribute to challenges with reproducibility across institutions. Notably, C57BL/6 Hsd mice and gene-targeted mice that have been backcrossed to this substrain have been reported to harbor a duplication in exons 28 and 29 of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30012848
DOI: 10.4049/jimmunol.1800014
PMCID: PMC6103850

Genes

NOD2
DOCK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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B Cell Defects Observed in Nod2 Knockout Mice Are a Consequence of a Dock2 Mutation Frequently Found in Inbred Strains.PMID 30012848Read ↗

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