Article

B cell defects observed in <i>Nod2</i> knockout mice are a consequence of a <i>Dock2</i> mutation frequently found in inbred strains

2018-01-04

Abstract excerpt

<h4>ABSTRACT</h4> Phenotypic differences among substrains of laboratory mice due to spontaneous mutations or pre-existing genetic variation confound the interpretation of targeted mutagenesis experiments, and contribute to challenges with reproducibility across institutions. Notably, C57BL/6NHsd mice and gene-targeted mice that have been backcrossed to this substrain have been reported to harbor a duplication in...

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Literature Corpus work: 1fc9c6db-3969-5638-adea-acaccf4ad9d6
DOI: 10.1101/242586

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