Article
Variation of the myelin oligodendrocyte glycoprotein gene is not primarily associated with multiple sclerosis in the Sardinian population.
BMC genetics - 17 May 2007
Marrosu Maria Giovanna, Murru Raffaele, Costa Gianna, Melis Maria Cristina, Rolesu Marcella, Schirru Lucia, Solla Elisabetta, Cuccu Stefania, Secci Maria Antonietta, Whalen Michael B, Cocco Eleonora, Pugliatti Maura, Sotgiu Stefano, Rosati Giulio, Cucca Francesco
Abstract excerpt
BACKGROUND: Multiple sclerosis (MS) is consistently associated with particular HLA-DRB1-DQB1 haplotypes. However, existing evidence suggests that variation at these loci does not entirely explain association of the HLA region with the disease. The MOG locus is a prime positional and functional candidate for such additional predisposing effects but the analysis is complicated by the strong, albeit labyrinthine...
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