Article
Ets-2 transdominant mutant abolishes anchorage-independent growth and macrophage colony-stimulating factor-stimulated invasion by BT20 breast carcinoma cells.
Cancer research - 1 Mar 1998
Sapi E, Flick M B, Rodov S, Kacinski B M
Abstract excerpt
Activation of the macrophage colony-stimulating factor receptor (CSF-1R) by its cognate ligand CSF-1 dramatically increases the tumorigenicity and invasive potential of both normal and neoplastic mammary epithelial cells. Recent studies have suggested that the Ets2 transcription factor plays a ce...
Topics
- Breast Neoplasms
- Cell Movement
- DNA-Binding Proteins
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Macrophage Colony-Stimulating Factor
- Mutation
- Neoplasm Invasiveness
- Proto-Oncogene Protein c-ets-2
- Proto-Oncogene Proteins
- Repressor Proteins
- Trans-Activators
- Transcription Factors
- Tumor Cells, Cultured