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Article

Ets-1 expression promotes epithelial cell transformation by inducing migration, invasion and anchorage-independent growth.

Oncogene - 11 Aug 2005

Hahne Jens Claus, Okuducu Ali Fuat, Kaminski Annette, Florin Alexandra, Soncin Fabrice, Wernert Nicolas

Abstract excerpt

Ets-1 is the prototype of the family of ETS transcription factors. In human tumors, Ets-1 is expressed in endothelial cells and fibroblasts of the tumor stroma and is proposed to play a role in tumor vascularization and invasion by upregulating expression of matrix-degrading proteases. In human carcinomas, Ets-1 is also expressed by neoplastic cells, but little is known about the functional implications of this...

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PMID: 15940256
DOI: 10.1038/sj.onc.1208761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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