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Article

Antisense expression for amphiregulin suppresses tumorigenicity of a transformed human breast epithelial cell line.

Oncogene - 11 Nov 1999

Ma L, Gauvillé C, Berthois Y, Millot G, Johnson G R, Calvo F

Abstract excerpt

The epidermal growth factor (EFG) family of receptors and their respective ligands play a major role in breast cancer progression and are the targets of new therapeutic approaches. Following immortalization with SV40 T antigen of normal human breast epithelial cells, a transformed variant cell line (NS2T2A1) was selected for its increased tumorigenicity in nude mice. This cell line was shown to have a higher...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Intercellular Signaling Peptides and Proteins

Share to Mice, Nude

Share to Neovascularization, Pathologic

Share to Receptors, Androgen

Share to RNA, Antisense

Source

Identifiers

PMID: 10597254
DOI: 10.1038/sj.onc.1203042

Genes

AR
EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Antisense expression for amphiregulin suppresses tumorigenicity of a transformed human breast epithelial cell line.PMID 10597254Read ↗

A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin.Semantic proximity Read ↗

The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.Semantic proximity Read ↗

The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory ActivitySemantic proximity Read ↗

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