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Article

Somatic mutation analysis of the APP and Presenilin 1 and 2 genes in Alzheimer's disease brains.

Journal of neurogenetics - 1 Jan 1998

Reznik-Wolf H, Machado J, Haroutunian V, DeMarco L, Walter G F, Goldman B, Davidson M, Johnston J A, Lannfelt L, Dani S U, Friedman E

Abstract excerpt

The molecular basis for sporadic Alzheimer disease (AD) remains largely unknown. We hypothesized that in some cases of sporadic AD, a somatic mutation in an embryonic cell committed to neuronal development within the amyloid precursor protein (APP), the presenilin 1 (PS-1) or the presenilin 2 (PS-2) genes (genes known to be involved in familial AD) may result in AD phenotype. Using PCR, denaturing gradient gel...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9666901
DOI: 10.3109/01677069809108555

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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