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Somatic and germline mosaicism in sporadic early-onset Alzheimer's disease

28 Apr 2004

Abstract excerpt

Alzheimer's disease (AD) is the commonest neurodegenerative disease worldwide. Rare familial cases may be caused by mutations in one of three genes-amyloid precursor protein, presenilin-1 and presenilin-2; however, the molecular basis of >99% of AD cases is unknown. Somatic mutation has been considered to be a mechanism that may account for a proportion of sporadic cases of AD, but to date there has been no...

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PMID: 15115757
DOI: 10.1093/hmg/ddh134

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