Article
Germline mutational analysis of presenilin 1 and APP genes in Jewish-Israeli individuals with familial or early-onset Alzheimer disease using denaturing gradient gel electrophoresis (DGGE).
European journal of human genetics : EJHG - 1 Jan 2000
Reznik-Wolf H, Treves T A, Shabtai H, Aharon-Peretz J, Chapman J, Davidson M, Barkai G, Hyslop P H, Goldman B, Korczyn A D, Friedman E
Abstract excerpt
Germ line mutations in three genes have been detected in patients with familial Alzheimer's disease (FAD) and sporadic, early onset disease: amyloid precursor protein (APP), presenilin 1 (PS-1), and presenilin 2 (PS-2). The relative proportions in which mutations in these genes occur among AD pat...
Topics
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- DNA Mutational Analysis
- Electrophoresis
- Female
- Genetic Testing
- Genotype
- Germ-Line Mutation
- Humans
- Israel