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Article

Amyloid precursor protein mutation at codon 713 (Ala-->Val) does not cause schizophrenia: non-pathogenic variant found at codon 705 (silent).

Neuroscience letters - 23 Jan 1995

Forsell C, Lannfelt L

Abstract excerpt

In some families with early-onset Alzheimer's disease (AD) pathogenic mutations have been found in exons 16 and 17 of the amyloid precursor protein (APP) gene. One case of schizophrenia has been described with a mutation at codon 713. We have developed a single strand conformation polymorphism (SSCP) method that detects mutations in these exons and investigated 98 AD cases and 56 elderly healthy controls. An...

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Identifiers

PMID: 7724053
DOI: 10.1016/0304-3940(94)11176-j

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Amyloid precursor protein mutation at codon 713 (Ala-->Val) does not cause schizophrenia: non-pathogenic variant found at codon 705 (silent).PMID 7724053Read ↗

Screening schizophrenic patients for mutations in the amyloid precursor protein gene.Semantic proximity Read ↗

C to T nucleotide substitution in codon 713 of amyloid precursor protein gene not found in 86 unrelated schizophrenics from multiplex families.Semantic proximity Read ↗

A novel silent variant at codon 711 and a variant at codon 708 of the APP sequence detected in Spanish Alzheimer and control cases.Semantic proximity Read ↗

No founder effect in three novel Alzheimer's disease families with APP 717 Val-->Ile mutation. Clerget-darpoux. French Alzheimer's Disease Study Group.Semantic proximity Read ↗

The Glu318Gly mutation of the presenilin-1 gene does not necessarily cause Alzheimer's disease.Semantic proximity Read ↗

Screening for the beta-amyloid precursor protein mutation (APP717: Val----Ile) in extended pedigrees with early onset Alzheimer's disease.Semantic proximity Read ↗

Absence of A673T amyloid-β precursor protein variant in Alzheimer's disease and other neurological diseases.Semantic proximity Read ↗

Screening for mutations at codon 717 of the amyloid precursor protein gene in Alzheimer's disease.Semantic proximity Read ↗

Absence of APP713 mutation in Italian and Russian families with schizophrenia.Semantic proximity Read ↗

Screening for the APP codon 670/671 mutations in Alzheimer's disease.Semantic proximity Read ↗

Sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene in 14 families with early onset Alzheimer's disease fails to reveal mutations in the beta-amyloid sequence.Semantic proximity Read ↗

Screening of amyloid precursor protein gene mutation (APP 717 Val-->Ile) in Swedish families with Alzheimer's disease.Semantic proximity Read ↗

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