Article
Molecular genetic analysis of the APP, PSEN1, and PSEN2 genes in Finnish patients with early-onset Alzheimer disease and frontotemporal lobar degeneration.
Alzheimer disease and associated disorders - 1 Jan 2000
Krüger Johanna, Moilanen Virpi, Majamaa Kari, Remes Anne M
Abstract excerpt
Mutations in 3 genes, amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2), have been identified as causing a proportion of early-onset Alzheimer disease (eoAD) cases. A few PSEN mutations have also been previously detected in patients with frontotemporal lobar degeneration (FTLD). In order to evaluate the role of these genes in a clinical series of Finnish eoAD and FTLD patients, we...
Topics
- Adult
- Aged
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- DNA Mutational Analysis
- Female
- Finland
- Frontotemporal Lobar Degeneration
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Presenilin-1
- Presenilin-2