Article
A mutation screening by DHPLC of PSEN1 and APP genes reveals no significant variation associated with the sporadic late-onset form of Alzheimer's disease.
Neuroscience letters - 18 May 2007
Scacchi Renato, Gambina Giuseppe, Moretto Giuseppe, Corbo Rosa Maria
Abstract excerpt
Alzheimer's disease (AD), the most common cause of dementia in the elderly, is usually divided into familial and sporadic forms, according to family history. The familial form has often been reportedly caused by mutations in amyloid precursor protein (APP), presenilin-1 (PSEN1), or presenilin-2 (PSEN2) genes, whereas the genetic component for the sporadic form is less clear. We carried out mutation screening in...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- DNA Mutational Analysis
- Female
- Genetic Variation
- Humans
- Male
- Mass Screening
- Middle Aged