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Screening Alzheimer's disease patients for mutations in the amyloid precursor protein gene.

Molecular and cellular probes - 1 Apr 1993

Jones C T, Morris S, Moffoot A, St Clair D, Brock D J

Abstract excerpt

Over the past two years a series of different mutations has been discovered in the amyloid precursor protein (APP) gene in patients with Alzheimer's disease. All have been clustered in exons 16 and 17, a region encoding the beta A4 peptide found in the amyloid deposits of neuritic plaques and cerebral blood vessels. We have used the powerful technique of denaturing gradient gel electrophoresis to screen for...

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Source

Identifiers

PMID: 8321254
DOI: 10.1006/mcpr.1993.1023

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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