Mutants with changes in different domains of yeast replication protein A exhibit differences in repairing the control region, the transcribed strand and the non-transcribed strand of the Saccharomyces cerevisiae MFA2 gene.

Abstract excerpt

We have analysed the removal of UV-induced cyclobutane pyrimidine dimers (CPDs) at nucleotide resolution from the MFA2 gene of wild-type Saccharomyces cerevisiae and in strains harbouring mutations in one of the yeast replication protein A (RPA) genes, RFA1. This gene codes for the 70 kDa subunit of RPA and it has previously been shown to have a role in nucleotide excision repair. Here two RFA1 mutants were...

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