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Article

Mutations in the gene encoding the 34 kDa subunit of yeast replication protein A cause defective S phase progression.

Journal of molecular biology - 8 Dec 1995

Santocanale C, Neecke H, Longhese M P, Lucchini G, Plevani P

Abstract excerpt

The in vivo function of the 34 kDa subunit of yeast replication protein A (RPA), encoded by the RFA2 gene, has been studied by analyzing the effect of Rpa34 depletion and by producing and characterizing rfa2 temperature-sensitive mutants. We show that unbalanced stoichiometry of the RPA subunits does not affect cell growth and cell cycle progression until the level of Rpa34 becomes rate-limiting, at which point...

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PMID: 7500336
DOI: 10.1006/jmbi.1995.0641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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