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Article

The RFC2 gene, encoding the third-largest subunit of the replication factor C complex, is required for an S-phase checkpoint in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Aug 1998

Noskov V N, Araki H, Sugino A

Abstract excerpt

Replication factor C (RF-C), an auxiliary factor for DNA polymerases delta and epsilon, is a multiprotein complex consisting of five different polypeptides. It recognizes a primer on a template DNA, binds to a primer terminus, and helps load proliferating cell nuclear antigen onto the DNA template. The RFC2 gene encodes the third-largest subunit of the RF-C complex. To elucidate the role of this subunit in DNA...

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Source

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Identifiers

PMID: 9671499
DOI: 10.1128/MCB.18.8.4914
PMCID: PMC109075

Genes

RFC2
RFC5
RFC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The RFC2 gene, encoding the third-largest subunit of the replication factor C complex, is required for an S-phase checkpoint in Saccharomyces cerevisiae.PMID 9671499Read ↗

Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints.Semantic proximity Read ↗

Allele-specific interactions between the yeast RFC1 and RFC5 genes suggest a basis for RFC subunit-subunit interactions.Semantic proximity Read ↗

The large subunit of replication factor C (Rfc1p/Cdc44p) is required for DNA replication and DNA repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

Destabilized PCNA trimers suppress defective Rfc1 proteins in vivo and in vitro.Semantic proximity Read ↗

ATP utilization by yeast replication factor C. IV. RFC ATP-binding mutants show defects in DNA replication, DNA repair, and checkpoint regulation.Semantic proximity Read ↗

The Schizosaccharomyces pombe rfc3+ gene encodes a homologue of the human hRFC36 and Saccharomyces cerevisiae Rfc3 subunits of replication factor C.Semantic proximity Read ↗

Dominant mutations in three different subunits of replication factor C suppress replication defects in yeast PCNA mutants.Semantic proximity Read ↗

Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway.Semantic proximity Read ↗

Fission yeast cdc24 is a replication factor C- and proliferating cell nuclear antigen-interacting factor essential for S-phase completion.Semantic proximity Read ↗

Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae.Semantic proximity Read ↗

Inactivating pentapeptide insertions in the fission yeast replication factor C subunit Rfc2 cluster near the ATP-binding site and arginine finger motif.Semantic proximity Read ↗

Identification of replication factor C from Saccharomyces cerevisiae: a component of the leading-strand DNA replication complex.Semantic proximity Read ↗

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