The intrinsic radioresistance of glioblastoma-derived cell lines is associated with a failure of p53 to induce p21 BAX expression

Abstract excerpt

Radiation is the primary modality of therapy for all commonly occurring malignant brain tumors, including medulloblastoma and glioblastoma. These two brain tumors, however, have a distinctly different response to radiation therapy. Medulloblastoma is very sensitive to radiation therapy, whereas glioblastoma is highly resistant, and the long-term survival of medulloblastoma patients exceeds 50%, while there are...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer-related Molecular Pathways
• Share to Molecular Biology Techniques and Applications
• Share to RNA Research and Splicing