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Article

Somatically acquired genetic alterations in flat colorectal neoplasias.

International journal of cancer - 29 Jul 1998

Olschwang S, Slezak P, Roze M, Jaramillo E, Nakano H, Koizumi K, Rubio C A, Laurent-Puig P, Thomas G

Abstract excerpt

Somatically acquired mutations in several genes have been reported as playing an important role during colorectal tumorigenesis. Two alternative groups of carcinomas, termed LOH+ and RER+, have been defined on the basis of their genetic anomalies, a biallelic inactivation of the APC or the TGF-betaRII genes, occurring as an alternative, in LOH+ or RER+ tumors. It is a generally accepted hypothesis that most of...

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Identifiers

PMID: 9663597
DOI: 10.1002/(sici)1097-0215(19980729)77:3<366::aid-ijc10>3.0.co;2-6

Genes

APC
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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