Article
Somatically acquired genetic alterations in flat colorectal neoplasias.
International journal of cancer - 29 Jul 1998
Olschwang S, Slezak P, Roze M, Jaramillo E, Nakano H, Koizumi K, Rubio C A, Laurent-Puig P, Thomas G
Abstract excerpt
Somatically acquired mutations in several genes have been reported as playing an important role during colorectal tumorigenesis. Two alternative groups of carcinomas, termed LOH+ and RER+, have been defined on the basis of their genetic anomalies, a biallelic inactivation of the APC or the TGF-be...
Topics
- Adenoma
- Adenomatous Polyposis Coli
- Adult
- Aged
- Aged, 80 and over
- Chromosome Deletion
- Colorectal Neoplasms
- Exons
- Female
- Genes, APC
- Genes, Tumor Suppressor
- Humans
- Japan
- Male
- Microsatellite Repeats
- Middle Aged
- Mutation
- Polymerase Chain Reaction