Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alternative genetic pathways in colorectal carcinogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 1997

Olschwang S, Hamelin R, Laurent-Puig P, Thuille B, De Rycke Y, Li Y J, Muzeau F, Girodet J, Salmon R J, Thomas G

Abstract excerpt

The comparative typing of matched tumor and blood DNAs at dinucleotide repeat (microsatellite) loci has revealed in tumor DNA the presence of alleles that are not observed in normal DNA. The occurrence of these additional alleles is possibly due to replication errors (RERs). Although this observation has led to the recognition of a subtype of colorectal cancer with a high incidence of RERs (caused by a deficiency...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Genes, p53

Share to Genes, ras

Share to Genotype

Share to Mutagenesis

Share to Point Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 9342373
DOI: 10.1073/pnas.94.22.12122
PMCID: PMC23723

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alternative genetic pathways in colorectal carcinogenesis.PMID 9342373Read ↗

APC mutations in colorectal tumors with mismatch repair deficiency.Semantic proximity Read ↗

A comparison of the genetic pathways involved in the pathogenesis of three types of colorectal cancer.Semantic proximity Read ↗

Differential prognosis of replication error phenotype and loss of heterozygosity in sporadic colorectal cancer.Semantic proximity Read ↗

Genomic instability occurs in colorectal carcinomas but not in adenomasSemantic proximity Read ↗

Frequency and prognostic impact of microsatellite instability in a large population-based study of endometrial carcinomas.Semantic proximity Read ↗

Replication error phenotype, clinicopathological variables, and patient outcome in Dukes' B stage II (T3,N0,M0) colorectal cancer.Semantic proximity Read ↗

Characteristics of metachronous colorectal carcinoma occurring despite colonoscopic surveillance.Semantic proximity Read ↗

Replication error in colorectal carcinoma: association with loss of heterozygosity at mismatch repair loci and clinicopathological variables.Semantic proximity Read ↗

Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumours.Semantic proximity Read ↗

Somatically acquired genetic alterations in flat colorectal neoplasias.Semantic proximity Read ↗

Different pathways of colorectal carcinogenesis and their clinical pictures.Semantic proximity Read ↗

Microsatellite instability in primary and metastatic colorectal cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.