Article
Microsatellite instability is associated with the macroscopic configuration of neoplasms in patients with multiple colorectal adenomas.
Japanese journal of clinical oncology - 1 Jul 1998
Sasaki S, Masaki T, Umetani N, Shinozaki M, Yokoyama T, Ono M, Nagawa H, Muto T
Abstract excerpt
BACKGROUND: The management of patients with multiple colorectal adenomas, 10-100 in number, is often troublesome clinically. To establish the reasonable management of such cases, genetic backgrounds should be made clear. METHODS: For a total of 19 adenomas and four carcinomas from four patients with multiple colorectal adenomas, we analyzed genetic instability at four selected microsatellite loci and screened...
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