Article
Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.
Cell metabolism - 3 Dec 2013
Zhang Quan, Ramracheya Reshma, Lahmann Carolina, Tarasov Andrei, Bengtsson Martin, Braha Orit, Braun Matthias, Brereton Melissa, Collins Stephan, Galvanovskis Juris, Gonzalez Alejandro, Groschner Lukas N, Rorsman Nils J G, Salehi Albert, Travers Mary E, Walker Jonathan N, Gloyn Anna L, Gribble Fiona, Johnson Paul R V, Reimann Frank, Ashcroft Frances M, Rorsman Patrik
Abstract excerpt
Glucagon, secreted by pancreatic islet α cells, is the principal hyperglycemic hormone. In diabetes, glucagon secretion is not suppressed at high glucose, exacerbating the consequences of insufficient insulin secretion, and is inadequate at low glucose, potentially leading to fatal hypoglycemia. The causal mechanisms remain unknown. Here we show that α cell KATP-channel activity is very low under hypoglycemic...
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