Article
In vitro affinity maturation of an anti-PSA antibody for prostate cancer diagnostic assay.
Journal of molecular biology - 9 Dec 2011
Muller Bruno H, Savatier Alexandra, L'Hostis Guillaume, Costa Narciso, Bossus Marc, Michel Sandrine, Ott Catherine, Becquart Laurence, Ruffion Alain, Stura Enrico A, Ducancel Frédéric
Abstract excerpt
Prostate-specific antigen (PSA) is a serum marker that is widely used for the diagnosis of prostatic diseases. Various subforms of free PSA, which are associated with prostate cancer differently, have been identified in sera. Thus, specific detection of certain subforms could permit discrimination between benign and malignant cases. Although the monoclonal antibody 5D3D11 displays the desired selectivity, its...
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