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Article

Imbalance of tRNA(Pro) isoacceptors induces +1 frameshifting at near-cognate codons.

Nucleic acids research - 1 Feb 2002

O'Connor Michael

Abstract excerpt

Increased expression of the CCU/CCA/CCG-decoding tRNA(Pr)(o)3 on a multicopy plasmid leads to suppression of several +1 frameshift mutations in Salmonella enterica serovar Typhimurium. Systematic analysis of the site of frameshifting indicates that excess tRNA(Pr)(o)3 promotes near-cognate decoding at CCC codons. Re-phasing of the reading frame can be achieved by a subsequent slippage of the tRNA onto a cognate...

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Identifiers

PMID: 11809889
DOI: 10.1093/nar/30.3.759
PMCID: PMC100296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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