Article
Doublet translocation at GGA is mediated directly by mutant tRNA(2Gly).
Journal of bacteriology - 1 Jun 1992
Pagel F T, Tuohy T M, Atkins J F, Murgola E J
Abstract excerpt
Members of the sufS class of -1 frameshift suppressors have alterations of the GGA/G-decoding tRNA(2Gly). Suppressor-promoted frameshifting at GGA was shown in this study to be directly mediated by the mutant tRNA(2Gly). We disproved the possibility that, in the presence of the compromised mutant tRNA(2Gly), either wild-type tRNA(1Gly), wild-type tRNA(3Gly), a GGA-reading mutant form of tRNA(3Gly), or any other...
Topics
- Escherichia coli
- Frameshift Mutation
- Genes, Suppressor
- Mutation
- Polymerase Chain Reaction
- RNA, Transfer, Gly
- Translocation, Genetic