Article
CIS-Acting Allele-Specific Expression Differences Induced by Alcohol and Impacted by Sex as Well as Parental Genotype of Origin.
Alcoholism, clinical and experimental research - 1 Aug 2018
Lo Chiao-Ling, Lumeng Lawrence, Bell Richard L, Liang Tiebing, Lossie Amy C, Muir Williams M, Zhou Feng C
Abstract excerpt
BACKGROUND: Alcohol use disorders (AUDs) are influenced by complex interactions between the genetics of the individual and their environment. We have previously identified hundreds of polygenic genetic variants between the selectively bred high- and low-alcohol drinking (HAD and LAD) rat lines. Here, we report allele-specific expression (ASE) differences, between the HAD2 and LAD2 rat lines. METHODS: The HAD2 and...
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