Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluation of a restricted likelihood ratio test for mapping quantitative trait loci with extreme discordant sib pairs.

Annals of human genetics - 1 Jan 1998

Knapp M

Abstract excerpt

Risch and Zhang recently proposed to use extreme discordant sib pairs for mapping quantitative trait loci. Here, it is shown that the set of genetically possible distributions of the number of marker alleles in such sib-pairs is described by two inequalities. Thus, a likelihood ratio test analogous to Holmans's possible triangle test for affected sib pairs can be defined. The performance of this test is compared...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Chromosome Mapping
Share to Genes, Dominant

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Recessive

Share to Likelihood Functions

Share to Mathematics

Share to Models, Genetic

Share to Quantitative Trait, Heritable

Source

Identifiers

PMID: 9659980
DOI: 10.1046/j.1469-1809.1998.6210075.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of a restricted likelihood ratio test for mapping quantitative trait loci with extreme discordant sib pairs.PMID 9659980Read ↗

The "possible triangle" test for extreme discordant sib pairs.Semantic proximity Read ↗

Affected-sib-pair test for linkage based on constraints for identical-by-descent distributions corresponding to disease models with imprinting.Semantic proximity Read ↗

Mapping quantitative-trait loci in humans by use of extreme concordant sib pairs: selected sampling by parental phenotypes.Semantic proximity Read ↗

An extension of the Maximum Lod Score method to X-linked loci.Semantic proximity Read ↗

Cost-effective sib-pair designs in the mapping of quantitative-trait loci.Semantic proximity Read ↗

Testing linkage and gene x environment interaction: comparison of different affected sib-pair methods.Semantic proximity Read ↗

Power and sample sizes for linkage with extreme sampling under an oligogenic model for quantitative traits.Semantic proximity Read ↗

Maximum-Likelihood-Binomial method for genetic model-free linkage analysis of quantitative traits in sibships.Semantic proximity Read ↗

A sib-pair approach to interval mapping of quantitative trait loci.Semantic proximity Read ↗

Optimal sibship selection for genotyping in quantitative trait locus linkage analysis.Semantic proximity Read ↗

Departure from the triangle constraints in discordant sib pairs: a test for genetic heterogeneity.Semantic proximity Read ↗

Sampling strategies for model free linkage analyses of quantitative traits: implications for sib pair studies of reading and spelling disabilities to minimize the total study cost.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.