Article
An extension of the Maximum Lod Score method to X-linked loci.
Annals of human genetics - 1 Oct 1995
Cordell H J, Kawaguchi Y, Todd J A, Farrall M
Abstract excerpt
The Maximum Lod Score method for affected relative-pair analysis, introduced by Risch, is a powerful method for detecting linkage between an autosomal marker locus and disease. In order to use the method to detect linkage to markers on the X-chromosome, some modification is necessary. Here we extend the method to be applicable to X-chromosomal data, and derive genetic restrictions on the haplotype-sharing...
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