Article
Polycyclic aromatic hydrocarbons: correlations between DNA adducts and ras oncogene mutations.
Mutation research - 8 Mar 1999
Ross J A, Nesnow S
Abstract excerpt
This review describes a series of studies on the tumorigenic activities of polycyclic aromatic hydrocarbons (PAHs) in various experimental animal model systems, their abilities to form PAH-DNA adducts in target tissues, and their abilities to mutate ras oncogenes in PAH-induced tumors. The review is limited to those PAHs that do not contain nitrogen, for which ras mutations have been detected in induced tumors,...
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