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Article

Subunit-selective contribution to channel gating of the M4 domain of the nicotinic receptor.

Biophysical journal - 1 Apr 2002

Bouzat Cecilia, Gumilar Fernanda, del Carmen Esandi María, Sine Steven M

Abstract excerpt

The muscle nicotinic receptor (AChR) is a pentamer of four different subunits, each of which contains four transmembrane domains (M1-M4). We recently showed that channel opening and closing rates of the AChR depend on a hydrogen bond involving a threonine at position 14' of the M4 domain in the alpha-subunit. To determine whether residues in equivalent positions in non-alpha-subunits contribute to channel gating,...

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Identifiers

PMID: 11916850
DOI: 10.1016/S0006-3495(02)75541-0
PMCID: PMC1301988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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