Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Binding sites contribute unequally to the gating of mouse nicotinic alpha D200N acetylcholine receptors.

The Journal of physiology - 1 Oct 1996

Akk G, Sine S, Auerbach A

Abstract excerpt

1. Single channel currents were recorded from HEK 293 cells expressing recombinant mouse adult (alpha 2 beta delta gamma) acetylcholine receptors (AChRs) containing a mutation at residue D200 of the alpha-subunit. Rate and equilibrium constants for AChR activation were estimated from open and closed time obtained over a range of ACh concentrations. 2. Mutation of alpha D200 to asparagine (alpha D200N)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Binding Sites
Share to Cell Line

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Biological

Share to Molecular Sequence Data

Share to Mutation

Share to Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 8910207
DOI: 10.1113/jphysiol.1996.sp021676
PMCID: PMC1160835

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Binding sites contribute unequally to the gating of mouse nicotinic alpha D200N acetylcholine receptors.PMID 8910207Read ↗

The role of loop 5 in acetylcholine receptor channel gating.Semantic proximity Read ↗

Mutations at lipid-exposed residues of the acetylcholine receptor affect its gating kinetics.Semantic proximity Read ↗

A distinct contribution of the delta subunit to acetylcholine receptor channel activation revealed by mutations of the M2 segment.Semantic proximity Read ↗

Functional differences between neurotransmitter binding sites of muscle acetylcholine receptors.Semantic proximity Read ↗

Subunit-selective contribution to channel gating of the M4 domain of the nicotinic receptor.Semantic proximity Read ↗

Unliganded gating of acetylcholine receptor channels.Semantic proximity Read ↗

Differential Contribution of Subunit Interfaces to α9α10 Nicotinic Acetylcholine Receptor Function.Semantic proximity Read ↗

Subunit-specific contribution to agonist binding and channel gating revealed by inherited mutation in muscle acetylcholine receptor M3-M4 linker.Semantic proximity Read ↗

Differential α4(+)/(-)β2 Agonist-binding Site Contributions to α4β2 Nicotinic Acetylcholine Receptor Function within and between Isoforms.Semantic proximity Read ↗

The kinetic properties of neuronal nicotinic receptors: genetic basis of functional diversity.Semantic proximity Read ↗

Influence of the gamma subunit and expression system on acetylcholine receptor gating.Semantic proximity Read ↗

Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.