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Article

The extracellular linker of muscle acetylcholine receptor channels is a gating control element.

The Journal of general physiology - 1 Sept 2000

Grosman C, Salamone F N, Sine S M, Auerbach A

Abstract excerpt

We describe the functional consequences of mutations in the linker between the second and third transmembrane segments (M2-M3L) of muscle acetylcholine receptors at the single-channel level. Hydrophobic mutations (Ile, Cys, and Phe) placed near the middle of the linker of the alpha subunit (alphaS269) prolong apparent openings elicited by low concentrations of acetylcholine (ACh), whereas hydrophilic mutations...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Myasthenic Syndromes, Congenital

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Source

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Identifiers

PMID: 10962011
DOI: 10.1085/jgp.116.3.327
PMCID: PMC2233691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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